Keiko Kobayashi Selected Research

Intrahepatic Cholestasis

11/2012	Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency.
12/2011	Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency.
8/2007	Citrin/mitochondrial glycerol-3-phosphate dehydrogenase double knock-out mice recapitulate features of human citrin deficiency.
12/2005	Variant clinical courses of 2 patients with neonatal intrahepatic cholestasis who have a novel mutation of SLC25A13.
10/2005	Metabolic derangements in deficiency of citrin, a liver-type mitochondrial aspartate-glutamate carrier.
1/2005	Frequency and distribution in East Asia of 12 mutations identified in the SLC25A13 gene of Japanese patients with citrin deficiency.
11/2004	Clinical heterogeneity of neonatal intrahepatic cholestasis caused by citrin deficiency: case reports from 16 patients.
10/2004	Effects of citrin deficiency in the perinatal period: feasibility of newborn mass screening for citrin deficiency.
5/2003	A novel inborn error of metabolism detected by elevated methionine and/or galactose in newborn screening: neonatal intrahepatic cholestasis caused by citrin deficiency.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Keiko Kobayashi Research Topics

Disease

35	Citrullinemia 01/2013 - 01/2002
28	Neonatal-onset citrullinemia type 2 01/2013 - 01/2002
24	Adult-onset citrullinemia type 2 01/2017 - 01/2002
13	Hyperammonemia 12/2011 - 11/2002
9	Intrahepatic Cholestasis 11/2012 - 05/2003
9	Fatty Liver 03/2011 - 09/2002
6	Necrosis 01/2016 - 01/2010
5	Neoplasms (Cancer) 04/2022 - 04/2004
5	Gas Gangrene (Gangrene, Gas) 10/2020 - 09/2012
5	Brain Diseases (Brain Disorder) 11/2010 - 03/2005
5	Cholestasis 04/2010 - 03/2005
5	Galactosemias (Galactosemia) 08/2009 - 10/2005
4	Hepatitis 01/2012 - 01/2008
4	Cardiomegaly (Heart Hypertrophy) 03/2011 - 09/2002
4	Neonatal hemochromatosis 01/2005 - 01/2002
3	Atherosclerosis 01/2016 - 01/2013
3	Liver Diseases (Liver Disease) 04/2010 - 02/2006
3	Type 2 Diabetes Mellitus (MODY) 01/2009 - 01/2008
3	Hypoglycemia (Reactive Hypoglycemia) 08/2007 - 12/2002
3	Jaundice (Icterus) 04/2006 - 11/2002
2	Inflammation (Inflammations) 01/2019 - 01/2015
2	Cognitive Dysfunction 01/2019 - 01/2019
2	Enterotoxemia 12/2016 - 11/2016
2	Alzheimer Disease (Alzheimer's Disease) 01/2016 - 01/2013
2	Non-alcoholic Fatty Liver Disease 01/2016 - 11/2008
2	Infections 01/2016 - 04/2005
2	Body Weight (Weight, Body) 11/2012 - 06/2009
2	Failure to Thrive 12/2010 - 03/2007
2	Hepatic Encephalopathy 01/2010 - 04/2004
2	Metabolic Diseases (Metabolic Disease) 08/2009 - 06/2007
2	Acute Liver Failure (Fulminant Hepatic Failure) 06/2009 - 11/2004
2	Hypertrophy 01/2009 - 02/2006
2	Proteinuria 01/2008 - 01/2007
2	Hepatocellular Carcinoma (Hepatoma) 12/2007 - 10/2003
2	Brain Edema (Cerebral Edema) 02/2006 - 03/2005
2	Hypoproteinemia 10/2005 - 11/2004
2	Coma (Comas) 10/2005 - 01/2002
1	Hypoxia (Hypoxemia) 04/2022
1	Male Infertility (Male Sterility) 03/2021
1	VLCAD deficiency 02/2021
1	Rhabdomyolysis 02/2021

Drug/Important Bio-Agent (IBA)

32	citrinIBA 01/2017 - 01/2002
15	aspartate-glutamate carrierIBA 01/2013 - 01/2002
13	Proteins (Proteins, Gene)FDA Link 04/2022 - 05/2003
13	CitrullineIBA 10/2012 - 01/2002
11	DNA (Deoxyribonucleic Acid)IBA 01/2013 - 01/2002
11	Urea (Carbamide)FDA LinkGeneric 11/2010 - 12/2002
9	EnzymesIBA 01/2016 - 12/2002
8	AmmoniaIBA 11/2010 - 01/2002
7	Carnitine (L-Carnitine)FDA LinkGeneric 03/2011 - 09/2002
6	CarbohydratesIBA 11/2012 - 05/2003
6	Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA 10/2005 - 12/2002
5	Glycerol (Glycerine)FDA LinkGeneric 01/2017 - 01/2002
5	Protein Isoforms (Isoforms)IBA 01/2013 - 01/2002
5	Pyruvic Acid (Pyruvate)IBA 11/2012 - 08/2007
5	Alanine Transaminase (SGPT)IBA 10/2012 - 06/2009
5	Messenger RNA (mRNA)IBA 03/2011 - 09/2002
5	Methionine (L-Methionine)FDA Link 12/2007 - 05/2003
4	Virulence Factors (Pathogenicity Factors)IBA 10/2020 - 09/2012
4	Amino Acids FDA Link 11/2012 - 05/2003
4	SodiumIBA 11/2012 - 01/2010
4	Aspartate Aminotransferases (Aspartate Transaminase)IBA 10/2012 - 06/2009
4	Bile Acids and Salts (Bile Acids)IBA 10/2012 - 10/2004
4	Threonine (L-Threonine)FDA Link 10/2012 - 10/2005
4	Galactose (Galactopyranose)FDA LinkGeneric 08/2009 - 05/2003
3	Fatty Acids (Saturated Fatty Acids)IBA 02/2021 - 08/2006
3	Sucrose (Saccharose)IBA 01/2017 - 08/2007
3	CeramidesIBA 01/2016 - 06/2009
3	Glycerolphosphate Dehydrogenase (Glycerol 3 Phosphate Dehydrogenase)IBA 11/2012 - 08/2007
3	Therapeutic UsesIBA 12/2011 - 04/2004
3	Arginine (L-Arginine)FDA Link 11/2010 - 11/2002
3	NAD (NADH)IBA 08/2007 - 12/2002
2	Toll-Like Receptor 4IBA 01/2021 - 01/2017
2	CytokinesIBA 01/2019 - 01/2015
2	Clostridium perfringens delta-toxin (CPDT)IBA 02/2018 - 01/2016
2	Type C PhospholipasesIBA 01/2015 - 05/2013
2	oxidized low density lipoproteinIBA 10/2014 - 01/2009
2	Clostridium perfringens alpha toxinIBA 05/2013 - 09/2012
2	Complementary DNA (cDNA)IBA 01/2013 - 04/2004
2	Triglycerides (Triacylglycerol)IBA 11/2012 - 02/2006
2	Glucose (Dextrose)FDA LinkGeneric 10/2012 - 03/2011
2	OrnithineIBA 08/2009 - 12/2002
2	Insulin (Novolin)FDA Link 07/2008 - 01/2008
2	Lactic Acid (Lactate)FDA LinkGeneric 08/2007 - 04/2006
2	Mannitol (Osmitrol)FDA LinkGeneric 02/2006 - 03/2005
2	Systemic carnitine deficiencyIBA 02/2006 - 12/2002
2	Aspartic Acid (Aspartate)FDA Link 04/2004 - 01/2002
2	malic acid (malate)IBA 04/2004 - 01/2002
2	Solute Carrier ProteinsIBA 12/2002 - 01/2002
1	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2022
1	Oxygen (Dioxygen)IBA 04/2022
1	SterolsIBA 03/2021
1	BezafibrateIBA 02/2021

Therapy/Procedure

14	Therapeutics 01/2019 - 01/2002
8	Liver Transplantation 12/2010 - 01/2002
3	Protein-Restricted Diet (Diet, Protein Restricted) 01/2010 - 11/2002
2	Palliative Care (Palliative Therapy) 11/2015 - 10/2003
2	Oral Administration 12/2011 - 06/2009
2	Carbohydrate-Restricted Diet (Low Carbohydrate Diet) 11/2010 - 05/2003
2	High-Protein Low-Carbohydrate Diet (Atkins Diet) 03/2007 - 05/2003